Euthyroid hyperthyroxinemia is defined as a condition in which the total serum or free thyroxine T4 concentration is abnormal without evidence of clinical thyroid disease.
Older men who are weak or delicate may manifest higher free thyroxine levels.
What are the causes of euthyroid hyperthyroxinemia?
Physiological causes: Pregnancy, Delayed puberty, Estrogen intake
Hereditary causes
Drugs: Heroin, methadone, perphenazine, Heparin, propranolol etc.
Thyroid hormone resistance syndrome
Hyperthyroxinemia of systemic illness like liver disease, acute psychosis, islet cell carcinoma, HIV
Miscellaneous.
What are the signs and symptoms of this condition?
Thyroid hormone resistance signs include following:
• Goiter
• Nystagmus
• Tachycardia
• Increased metabolic rate
• Deafness
• Liver disease signs include the following:
• Icterus
• Hepatomegaly
Management of euthyroid hyperthyroxinemia.
• Obtain a detailed clinical evaluation
• Measurement of TSH by a third generation assay
• Measurement of free T4
The tumors, such as glucagonoma, islet cell tumors, or estrogen-secreting tumors, may be resectable.
• Most of the conditions are self-limiting.
• Hyperthyroidism
