Euthyroid Sick Syndrome

Euthyroid sick syndrome is a state of adaptation or dysregulation of thyrotropic feedback control where the levels of T3 and T4 are at unusual levels. Serum cortisol is often elevated in euthyroid sick syndrome and low or low-normal in hypothyroidism due to pituitary-hypothalamic disease.

 

 

What is euthyroid sick syndrome?

Euthyroid sick syndrome is a state of adaptation or dysregulation of thyrotropic feedback control where the levels of T3 and T4 are at unusual levels but the thyroid gland does not appear to be dysfunctional.

Age /sex of euthyroid sick syndrome?

It can affect people at any age.

What are the causes of euthyroid sick syndrome?

Include several chronic and acute conditions:

-Pneumonia

-Fasting

-Starvation

-Sepsis

-Stress

-Heart failure

-Cardiopulmonary bypass

-Malignancy

-Trauma

-Myocardial infarction

-Chronic renal failure

-Cirrhosis

-Diabetic ketoacidosis

What are the signs and symptoms of euthyroid sick syndrome?

Symptoms include:

-Hypothermia (decreased body temperature)

-reduced heart rate

-reduced muscle strength

-respiratory depression

Investigations for Euthyroid Sick syndrome?

-Typical non-thyroid illness (NTI) findings are T4 level within the reference range low T3 level, slightly reduced or reference range level of TSH, elevated rT3 level, and sometimes free T4 level is also raised.

-In severe NTI, the findings are low T4, low T3, reduced TSH, elevated rT3, and free T4 that is within the reference range or is diminished.

What is the treatment for euthyroid sick syndrome?

No specific treatment is there for euthyroid sick syndrome. Medication will give only symptomatic relief.

 

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