What is Dubin Johnson syndrome?
Dubin-Johnson syndrome is a rare genetic disorder of the liver which is passed down through families (inherited)
A person who has been affected has mild jaundice throughout life.
Who is affected by Dubin-Johnson syndrome?
Dubin –Johnson syndrome is described in all races and both sexes
What are the causes of Dubin-Johnson syndrome?
Dubin-Johnson syndrome occurs due to excess circulation and accumulation of bilirubin (hyperbilirubinemia ) which results in yellow-orange discolouration of tissues.
Risk factors –
• Alcohol
• Birth control pills
• Infection
• Pregnancy
• Environmental factors
What are the signs and symptoms of Dubin-Johnson syndrome?
• Mild jaundice is the only symptom
• Some of the patients complain of –weakness and abdominal pains.
• Only occasionally patients have Hepatosplenomegaly
What investigations are advised for Dubin-Johnson syndrome?
• Physical examination
• Liver biopsy
• Blood test
• Serum bilirubin
• Liver function test
• Laparoscopy examination of the liver
What treatment is advised for Dubin Johnson syndrome?
No specific treatment
What is the prognosis of Dubin Johnson syndrome?
Prognosis is good
What are the complications of Dubin Johnson syndrome?
• Severe jaundice
• Reduced liver function
What is the differential diagnosis of Dubin Johnson syndrome?
• Rotor syndrome
• Obstructive cholestasis stones
• Metastatic liver disease
• Hepatocellular carcinoma
• Sepsis
• Autoimmune hepatitis
• Alcoholism and other hepatotoxic exposure
• Viral hepatitis
• Hepatic storage disease
What is the diet and management of Dubin Johnson syndrome?
Genetic counseling
What are the commonly indicated Homeopathy remedies for the symptomatic management of Dubin Johnson syndrome?
Chelidonium Majus
Chioanthus virginica
Lycopodium
Phosphorus
